3/24/2023 0 Comments Decode logoIf you do not receive a response from the seller for your return request within two business days, you can submit an A-to-Z Guarantee claim. Learn more about returning seller fulfilled items. Note: For seller fulfilled items from Books, Movies & TV Shows categories, the sellers need to be informed of the damage/ defect within 14 days of delivery.įor seller-fulfilled items from Fine Art category, the sellers need to be informed of the damage / defect within 10 days of delivery. These items are not eligible for self-return. Color psychology is a branch of research that helps us to define the influence of colors on actions and decisions. The seller will arrange the return pick up for these items.įor seller-fulfilled items from Sports collectibles and Entertainment collectibles categories, the sellers need to be informed of the damage / defect within 10 days of delivery. Marketers use color psychology to influence the buying behavior of their target consumers. Text Decoder is a reliable, efficient, and user-friendly tool. Use of certain colors for specific brands can impact the purchase decision of the customers. You can use this tool by simply writing or pasting the input box’s content, and the resulting decoded text will be displayed immediately. You can easily copy it by pressing the copy button. identify novel biomarkers of each cluster ĭECODE will involve end users and engage with regulator and decision makers to ensure maximum exploitation and impact, taking into account ethical,legal and social implications.Moreover, you should know that there are no charges associated with this tool, so you can. stratify patients into clusters and provide easy to handle platform to assign patients to each them This proposal will offer also the unique opportunity to study a larger cohort of patients that will be in depth characterized for genetic and immune abnormalities in the various complement components, and for their clinical and biochemical characteristics. WES, proteomics and metabolomics) and hierarchical clustering analysis to define a precise stratification of patients with C3G/IC-MPGN, and to identify specific biomarkers, which will be instrumental for diagnosis, predicting prognosis and tailoring the right therapeutic strategy for the right patients, towards personalized medicine. Building on this previous experience, here we will implement this strategy by combining omics approaches (i.e. Previous studies by the Coordinator have been capable of identifying four patient clusters, instrumental to define early and late complement activation. In the hope that the same could apply to patients with MPGN the main goal of DECODE is to improve the diagnosis and management of these very patients through precise stratification and tailored treatment protocols. These diseases are untreatable at the moment despite a plethora of complement inhibitors developed by many companies boosted by the success of the C5 inhibitor eculizumab that was literally transformative of the natural history of patients with atypical HUS. Primary membranoproliferative glomerulonephritis represents a heterogenous group of rare kidney disorders classified into alternative pathway complement-mediated C3 glomerulopathy (C3G) and immune-complex-mediated MPGN (IC-MPGN). Istituto di Ricerche Farmacologiche Mario Negri IRCCS Pathology of interest:Ĭ3 Glomerulopathies/immune complex-mediated glomerular diseases įRRB also finances partner number 1: ASST-Papa Giovanni XXIII. The Principal Investigator is Dr. The Principal Investigator responsible of the project is Dr. Ariela Benigni. I n this project FRRB finances the Coordinator: Istituto di Ricerche Farmacologiche Mario Negri IRCCS. Defining stratification of patients with C3 Glomerulopathies/immune complex-mediated glomerular diseases for better diagnosis and tailored treatment.
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